Open AccessQuercetin Enhances Exercise-Mediated Neuroprotective Effects in Brain Ischemic Rats
Author(s) -
Heng Chih Chang,
Yea Ru Yang,
Paulus S. Wang,
Ray Yau Wang
Publication year - 2014
Publication title -
medicine and science in sports and exercise
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000000310
Subject(s) - quercetin , neuroprotection , oxidative stress , pharmacology , pi3k/akt/mtor pathway , medicine , protein kinase b , ischemia , ly294002 , apoptosis , antioxidant , chemistry , biochemistry
Reactive oxygen species are markedly increased after ischemia and play important roles in the mechanism of ischemia-reperfusion injury. Regulating the oxidative stress response after brain ischemia provides a potential therapeutic strategy. Quercetin is a natural flavonoid that exhibits antioxidant properties. However, the mechanisms by which it protects cells are not fully understood. Exercise training also reduces oxidative stress and enhances brain recovery. The purpose of this study was to determine whether combined exercise training with quercetin treatment could result in better neuroprotection and functional recovery in rats subjected to brain ischemia.