Open AccessEndurance Exercise Mimetics in Skeletal Muscle
Author(s) -
Antonios Matsakas,
Vihang A. Narkar
Publication year - 2010
Publication title -
current sports medicine reports
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.424
H-Index - 51
eISSN - 1537-8918
pISSN - 1537-890X
DOI - 10.1249/jsr.0b013e3181e93938
Subject(s) - ampk , skeletal muscle , coactivator , regulator , activator (genetics) , peroxisome proliferator activated receptor , medicine , amp activated protein kinase , protein kinase a , peroxisome , receptor , endocrinology , transcription factor , bioinformatics , microbiology and biotechnology , biology , kinase , biochemistry , gene
Regular exercise promotes favorable structural and metabolic adaptations, especially in the skeletal muscle, to boost endurance and cardiovascular health. These changes are driven by a network of incompletely understood molecular pathways that trigger transcriptional remodeling of the skeletal muscle. In this article, we describe recent advances in the understanding of the key components of this circuitry [namely peroxisome proliferator activator receptor delta (PPARdelta), adenosine monophosphate (AMP)-activated protein kinase (AMPK), silent information regulator two protein 1 (SIRT1), and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)] that govern aerobic transformation of the skeletal muscles. We also discuss recent discoveries that raise the possibility of synthetically mimicking exercise with pathway-specific drugs to improve aerobic capacity and, in turn, health.