Open AccessA Role for Exercise to Counter Skeletal Muscle Clock Disruption
Author(s) -
Melissa L. Erickson,
Karyn A. Esser,
William E. Kraus,
Thomas W. Buford,
Leanne M. Redman
Publication year - 2020
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000235
Subject(s) - skeletal muscle , endocrinology , medicine , circadian clock , energy expenditure , carbohydrate metabolism , exercise intolerance , circadian rhythm , chemistry , biology , heart failure
Disruption of the skeletal muscle circadian clock leads to a preferential shift toward lipid oxidation while reducing carbohydrate oxidation. These effects are apparent at the whole-body level, including glucose intolerance, increased energy expenditure, and fasting hyperglycemia. We hypothesize that exercise counters these metabolic disturbances by modifying the skeletal muscle clock and reverting substrate metabolism back toward an optimal substrate balance.