Open AccessMacrophage Regulation of Muscle Regrowth From Disuse in Aging
Author(s) -
Paul T. Reidy,
Esther E. DupontVersteegden,
Micah J. Drummond
Publication year - 2019
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000201
Subject(s) - skeletal muscle , macrophage , immune system , microbiology and biotechnology , biology , medicine , endocrinology , immunology , biochemistry , in vitro
Skeletal muscle immune cells, such as macrophages, are necessary for proper regrowth after muscle disuse. We suggest that the important role of macrophages concerning muscle regrowth after disuse is divergent compared with young mice (i.e., dysregulated) during the recovery period. Modulation of macrophages may be a promising future therapeutic target to enhance the impaired muscle growth during recovery from disuse in older adults.