Open AccessResistance Exercise-Induced Hypertrophy: A Potential Role for Rapamycin-Insensitive mTOR
Author(s) -
Riki Ogasawara,
Thomas E. Jensen,
Craig A. Goodman,
Troy A. Hornberger
Publication year - 2019
Publication title -
exercise and sport sciences reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000189
Subject(s) - pi3k/akt/mtor pathway , sirolimus , rptor , muscle hypertrophy , mechanistic target of rapamycin , signal transduction , mtorc1 , microbiology and biotechnology , biology , medicine , endocrinology
The mechanistic target of rapamycin (mTOR) exerts both rapamycin-sensitive and rapamycin-insensitive signaling events, and the rapamycin-sensitive components of mTOR signaling have been widely implicated in the pathway through which resistance exercise induces skeletal muscle hypertrophy. This review explores the hypothesis that rapamycin-insensitive components of mTOR signaling also contribute to this highly important process.