Open AccessResistance Exercise’s Ability to Reverse Cancer-Induced Anabolic Resistance
Author(s) -
Ryan Montalvo,
Justin P. Hardee,
Brandon N. VanderVeen,
James A. Carson
Publication year - 2018
Publication title -
exercise and sport sciences reviews
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.945
H-Index - 99
eISSN - 1538-3008
pISSN - 0091-6331
DOI - 10.1249/jes.0000000000000159
Subject(s) - anabolism , wasting , resistance training , anabolic agents , skeletal muscle , cancer , endocrinology , medicine , chemistry
Skeletal muscle has the dynamic capability to modulate protein turnover in response to anabolic stimuli, such as feeding and contraction. We propose that anabolic resistance, the suppressed ability to induce protein synthesis, is central to cancer-induced muscle wasting. Furthermore, we propose that resistance exercise training has the potential to attenuate or treat cancer-induced anabolic resistance through improvements in oxidative metabolism.