Open AccessLeukocyte's Hif-1 Expression and Training-Induced Erythropoietic Response in Swimmers
Author(s) -
Rémi Mounier,
Vincent Pialoux,
Anne Cayre,
Laurent Schmitt,
JeanPaul Richalet,
Paul Robach,
Françoise Lasne,
Belle Roels,
Grégoire P. Millet,
J Coudert,
Eric Clottes,
Nicole Fellmann
Publication year - 2006
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/01.mss.0000228955.98215.a1
Subject(s) - erythropoietin , altitude training , hypoxia (environmental) , medicine , vo2 max , erythropoiesis , hemoglobin , endocrinology , athletes , chemistry , physical therapy , oxygen , anemia , heart rate , organic chemistry , blood pressure
Altitude training is popular among athletes to augment oxygen delivery capabilities to tissues and to improve physical performance. Hypoxia inducible factor-1 (HIF-1) controls the expression of several genes' encoding involved in physiological responses towards reduced oxygen availability, in particular by increasing serum erythropoietin (EPO). It may be involved in the individual variability for erythropoietic markers and/or sea-level performance of athletes using altitude during their training. Therefore, we investigated whether, before training, evolutions of hif-1alpha and ahif (HIF-1alpha natural antisense) transcript amounts and HIF-1alpha protein quantities in leukocytes measured during an acute hypoxia normobaric test (3 h at 3000 m at rest) could allow to predict poor and good responders for hematological markers after a "living high-training low" protocol.