Open AccessPrognostic Utility of Pre- and Postoperative Circulating Tumor DNA Liquid Biopsies in Patients with Peritoneal Metastases
Author(s) -
Joel Baumgartner,
Paul Riviere,
Richard B. Lanman,
Kaitlyn J. Kelly,
Jula Veerapong,
Andrew M. Lowy,
Razelle Kurzrock
Publication year - 2020
Publication title -
annals of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.764
H-Index - 173
eISSN - 1534-4681
pISSN - 1068-9265
DOI - 10.1245/s10434-020-08331-x
Subject(s) - medicine , perioperative , surgical oncology , hazard ratio , context (archaeology) , proportional hazards model , oncology , gastroenterology , surgery , confidence interval , paleontology , biology
Circulating tumor DNA (ctDNA) is a promising technology for treatment selection, prognostication, and surveillance after definitive therapy. Its use in the perioperative setting for patients with metastatic disease has not been well studied. We characterize perioperative plasma ctDNA and its association with progression-free survival (PFS) in patients undergoing surgery for peritoneal metastases.