Open AccessModel of Patient-Specific Immune-Enhanced Organoids for Immunotherapy Screening: Feasibility Study
Author(s) -
Konstantinos I. Votanopoulos,
Steven D. Forsythe,
Hemamylammal Sivakumar,
Andrea Mazzocchi,
Julio Aleman,
Lance D. Miller,
Edward A. Levine,
Pierre L. Triozzi,
Aleksander Skardal
Publication year - 2019
Publication title -
annals of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.764
H-Index - 173
eISSN - 1534-4681
pISSN - 1068-9265
DOI - 10.1245/s10434-019-08143-8
Subject(s) - organoid , medicine , lymph node , melanoma , immune system , immunotherapy , nivolumab , cancer research , ipilimumab , pathology , immunology , biology , microbiology and biotechnology
We hypothesized that engineering a combined lymph node/melanoma organoid from the same patient would allow tumor, stroma, and immune system to remain viable for personalized immunotherapy screening.