Open AccessMathematical Modeling of the Metastatic Colorectal Cancer Microenvironment Defines the Importance of Cytotoxic Lymphocyte Infiltration and Presence of PD-L1 on Antigen Presenting Cells
Author(s) -
Jenny Lazarus,
Morgan Oneka,
Souptik Barua,
Tomasz Maj,
Mirna Perusina Lanfranca,
Lawrence Delrosario,
Lei Sun,
J. Joshua Smith,
Michael I. D’Angelica,
Jinru Shia,
Jiayun M Fang,
Jiaqi Shi,
Marina Pasca di Magliano,
Weiping Zou,
Arvind Rao,
Timothy L. Frankel
Publication year - 2019
Publication title -
annals of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.764
H-Index - 173
eISSN - 1534-4681
pISSN - 1068-9265
DOI - 10.1245/s10434-019-07508-3
Subject(s) - ctl* , medicine , immune system , cytotoxic t cell , tumor microenvironment , surgical oncology , colorectal cancer , antigen , immune checkpoint , cancer research , immunology , immunotherapy , cancer , oncology , biology , cd8 , in vitro , biochemistry
Although immune-based therapy has proven efficacious for some patients with microsatellite instability (MSI) colon cancers, a majority of patients receive limited benefit. Conversely, select patients with microsatellite stable (MSS) tumors respond to checkpoint blockade, necessitating novel ways to study the immune tumor microenvironment (TME). We used phenotypic and spatial data from infiltrating immune and tumor cells to model cellular mixing to predict disease specific outcomes in patients with colorectal liver metastases.