Open AccessManagement of Sentinel Lymph Node Metastasis in Merkel Cell Carcinoma: Completion Lymphadenectomy, Radiation, or Both?
Author(s) -
Matthew C. Perez,
Daniel Oliver,
Evan Weitman,
David Boulware,
Jane L. Messina,
Javier F. Torres-Roca,
C. Wayne Cruse,
Ricardo J. Gonzalez,
Amod A. Sarnaik,
Ver K. Sondak,
Evan Wuthrick,
Louis B. Harrison,
Jonathan S. Zager
Publication year - 2018
Publication title -
annals of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.764
H-Index - 173
eISSN - 1534-4681
pISSN - 1068-9265
DOI - 10.1245/s10434-018-6810-1
Subject(s) - medicine , merkel cell carcinoma , lymphadenectomy , sentinel lymph node , radiation therapy , sentinel node , lymphovascular invasion , surgery , biopsy , lymph node , carcinoma , radiology , cancer , metastasis , breast cancer
Approximately 30% of patients with clinically localized Merkel cell carcinoma (MCC) show nodal involvement on sentinel lymph node biopsy (SLNB). Optimal management of SLNB-positive disease has not been defined. This study compared outcomes after completion lymphadenectomy (CLND), radiation, and combined CLND plus radiation after a positive SLNB.