Downregulation of collagen XI during late postnatal corneal development is followed by upregulation after injury | Zendy

Mei Sun | Zendy; Devon Cogswell | Zendy; Sheila M. Adams | Zendy; Yasmin Ayoubi | Zendy; Ambuj Kumar | Zendy; Tea Reljic | Zendy; Marcel Y. Ávila | Zendy; Curtis E. Margo | Zendy; Edgar M. Espana | Zendy

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Downregulation of collagen XI during late postnatal corneal development is followed by upregulation after injury

Author(s) -

Mei Sun,

Devon Cogswell,

Sheila M. Adams,

Yasmin Ayoubi,

Ambuj Kumar,

Tea Reljic,

Marcel Y. Ávila,

Curtis E. Margo,

Edgar M. Espana

Publication year - 2021

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.258694

Subject(s) - fibrillogenesis , downregulation and upregulation , fibril , collagen vi , stromal cell , microbiology and biotechnology , collagen fibril , extracellular matrix , knockout mouse , biology , collagen, type i, alpha 1 , stroma , wound healing , matrix (chemical analysis) , pathology , anatomy , chemistry , immunohistochemistry , biochemistry , immunology , medicine , cancer research , gene , chromatography

Collagen XI plays a role in nucleating collagen fibrils and in controlling fibril diameter. The aim of this research was to elucidate the role that collagen XI plays in corneal fibrillogenesis during development and following injury. The temporal and spatial expression of collagen XI was evaluated in C57BL/6 wild-type mice. For wound-healing studies in adult mice, stromal injuries were created using techniques that avoid caustic chemicals. The temporal expression and spatial localization of collagen XI was studied following injury in a Col11a1 inducible knockout mouse model. We found that collagen XI expression occurs during early maturation and is upregulated after stromal injury in areas of regeneration and remodeling. Abnormal fibrillogenesis with new fibrils of heterogeneous size and shape occurs after injury in a decreased collagen XI matrix. In conclusion, collagen XI is expressed in the stroma during development and following injury in adults, and is a regulator of collagen fibrillogenesis in regenerating corneal tissue.

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