Distribution of guanylate cyclase within photoreceptor outer segments | Zendy

Mark A. Hallett | Zendy; Joan L. Delaat | Zendy; Kentaro Arikawa | Zendy; Cassandra L. Schlamp | Zendy; Fansheng Kong | Zendy; David S. Williams | Zendy

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Distribution of guanylate cyclase within photoreceptor outer segments

Author(s) -

Mark A. Hallett,

Joan L. Delaat,

Kentaro Arikawa,

Cassandra L. Schlamp,

Fansheng Kong,

David S. Williams

Publication year - 1996

Publication title -

journal of cell science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.384

H-Index - 278

eISSN - 1477-9137

pISSN - 0021-9533

DOI - 10.1242/jcs.109.7.1803

Subject(s) - biology , gucy1b3 , gucy1a3 , guanylate cyclase , cytoskeleton , microbiology and biotechnology , actin , gucy2d , guanylate cyclase 2c , biophysics , enzyme , cell , biochemistry

Guanylate cyclases play an essential role in the recovery of vertebrate photoreceptor cells after light activation. Here, we have investigated how one such guanylate cyclase, RetGC-1, is distributed within light- and dark-adapted rod photoreceptor cells. Guanylate cyclase activity partitioned with the photoreceptor outer segment (OS) cytoskeleton in a light-sensitive manner. RetGC-1 was found to bind actin filaments in actin blot overlays, suggesting a mechanism for its association with the OS cytoskeleton. In retinal sections, this enzyme was immunodetected only in the OSs, where it appeared to be distributed throughout the disk membranes.

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