Open AccessAdhesion signaling – crosstalk between integrins, Src and Rho
Author(s) -
Stephan Huveneers,
Erik H.J. Danen
Publication year - 2009
Publication title -
journal of cell science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.384
H-Index - 278
eISSN - 1477-9137
pISSN - 0021-9533
DOI - 10.1242/jcs.039446
Subject(s) - crosstalk , biology , integrin , microbiology and biotechnology , extracellular matrix , signal transduction , mechanotransduction , cell adhesion , proto oncogene tyrosine protein kinase src , focal adhesion , transmembrane protein , gtpase , cytoskeleton , receptor , cell , biochemistry , physics , optics
Interactions between cells and the extracellular matrix coordinate signaling pathways that control various aspects of cellular behavior. Integrins sense the physical properties of the extracellular matrix and organize the cytoskeleton accordingly. In turn, this modulates signaling pathways that are triggered by various other transmembrane receptors and augments the cellular response to growth factors. Over the past years, it has become clear that there is extensive crosstalk between integrins, Src-family kinases and Rho-family GTPases at the heart of such adhesion signaling. In this Commentary, we discuss recent advances in our understanding of the dynamic regulation of the molecular connections between these three protein families. We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.