Open AccessShort-term and bystander effects of radiation on murine submandibular glands
Author(s) -
Hitoshi Uchida,
Matthew H. Ingalls,
Eri O. Maruyama,
Carl J. Johnston,
Eric Hernady,
Roberta C. Faustoferri,
Catherine E. Ovitt
Publication year - 2022
Publication title -
disease models and mechanisms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.327
H-Index - 83
eISSN - 1754-8411
pISSN - 1754-8403
DOI - 10.1242/dmm.049570
Subject(s) - bystander effect , saliva , irradiation , salivary gland , submandibular gland , secretion , radiation therapy , head and neck , medicine , chemistry , cancer research , pathology , immunology , surgery , physics , nuclear physics
Many patients treated for head and neck cancers experience salivary gland hypofunction due to radiation damage. Understanding the mechanisms of cellular damage induced by radiation treatment is important in order to design methods of radioprotection. In addition, it is crucial to recognize the indirect effects of irradiation and the systemic responses that may alter saliva secretion. In this study, radiation was delivered to murine submandibular glands (SMGs) bilaterally, using a 137Cs gamma ray irradiator, or unilaterally, using a small-animal radiation research platform (SARRP). Analysis at 3, 24 and 48 h showed dynamic changes in mRNA and protein expression in SMGs irradiated bilaterally. Unilateral irradiation using the SARRP caused similar changes in the irradiated SMGs, as well as significant off-target, bystander effects in the non-irradiated contralateral SMGs.