Open AccessMembrane trafficking in health and disease
Author(s) -
Rebecca Yarwood,
John Hellicar,
Philip Woodman,
Martin Lowe
Publication year - 2020
Publication title -
disease models and mechanisms
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.327
H-Index - 83
eISSN - 1754-8411
pISSN - 1754-8403
DOI - 10.1242/dmm.043448
Subject(s) - function (biology) , disease , biology , microbiology and biotechnology , medicine , pathology
Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment. In this At a Glance article and accompanying poster, we outline the major cellular trafficking pathways and discuss how defects in the function of the molecular machinery that mediates this transport lead to various diseases in humans. We also briefly discuss possible therapeutic approaches that may be used in the future treatment of trafficking-based disorders.