Open AccessHedgehog produced by the Drosophila wing imaginal disc induces distinct responses in three target tissues
Author(s) -
Ryo Hatori,
Thomas B. Kornberg
Publication year - 2020
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.754
H-Index - 325
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.195974
Subject(s) - imaginal disc , biology , hedgehog , primordium , microbiology and biotechnology , signal transduction , wing , hedgehog signaling pathway , drosophila melanogaster , decapentaplegic , compartment (ship) , anatomy , myocyte , patched , drosophila (subgenus) , genetics , gene , aerospace engineering , engineering , oceanography , geology
Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac primordium (ASP) and myoblasts. Hh distributes in concentration gradients in the anterior compartment of the wing disc, ASP and myoblasts, and activates genes in each tissue. Some targets of Hh signal transduction are common to the disc, ASP and myoblasts, whereas others are tissue-specific. Signaling in the three tissues is cytoneme-mediated and cytoneme-dependent. Some ASP cells project cytonemes that receive both Hh and Branchless (Bnl), and some targets regulated by Hh signaling in the ASP are also dependent on Bnl signal transduction. We conclude that the single source of Hh in the wing disc regulates cell type-specific responses in three discreet target tissues.