Parallels between wound healing, epimorphic regeneration and solid tumors | Zendy

Alan Y. Wong | Zendy; Jessica L. Whited | Zendy

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Parallels between wound healing, epimorphic regeneration and solid tumors

Author(s) -

Alan Y. Wong,

Jessica L. Whited

Publication year - 2020

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.181636

Subject(s) - biology , regeneration (biology) , wound healing , carcinogenesis , immune system , tissue repair , immune modulation , immunology , cancer , cancer research , microbiology and biotechnology , parallels , genetics , mechanical engineering , engineering

Striking similarities between wound healing, epimorphic regeneration and the progression of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic effects of tumorigenesis that are now being appreciated in epimorphic regeneration, including genetic, cellular and metabolic heterogeneity, changes in circulating factors, and the complex roles of immune cells and immune modulation at systemic and local levels. We suggest that certain mechanisms enabling regeneration may be co-opted by cancer to promote growth at primary and metastatic sites. Finally, we advocate that working with a unified approach could complement research in both fields.

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