Open AccessCharacterization of the ventricular-subventricular stem cell niche during human brain development
Author(s) -
Amanda Coletti,
Deepinder Singh,
Saurabh Kumar,
Tasnuva Nuhat Shafin,
Patrick J. Briody,
Benjamin F. Babbitt,
Derek Pan,
Emily S. Norton,
Eliot C. Brown,
Kristopher T. Kahle,
Marc R. Del Bigio,
Joanne C. Conover
Publication year - 2018
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.754
H-Index - 325
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.170100
Subject(s) - subventricular zone , biology , neurogenesis , lateral ventricles , stem cell , neural stem cell , ependymal cell , niche , neuroscience , human brain , anatomy , microbiology and biotechnology , central nervous system , ecology
Human brain development proceeds via a sequentially transforming stem cell population in the ventricular-subventricular zone (V-SVZ). An essential, but understudied, contributor to V-SVZ stem cell niche health is the multi-ciliated ependymal epithelium, which replaces stem cells at the ventricular surface during development. However, reorganization of the V-SVZ stem cell niche and its relationship to ependymogenesis has not been characterized in the human brain. Based on comprehensive comparative spatiotemporal analyses of cytoarchitectural changes along the mouse and human ventricle surface, we uncovered a distinctive stem cell retention pattern in humans as ependymal cells populate the surface of the ventricle in an occipital-to-frontal wave. During perinatal development, ventricle-contacting stem cells are reduced. By 7 months few stem cells are detected, paralleling the decline in neurogenesis. In adolescence and adulthood, stem cells and neurogenesis are not observed along the lateral wall. Volume, surface area and curvature of the lateral ventricles all significantly change during fetal development but stabilize after 1 year, corresponding with the wave of ependymogenesis and stem cell reduction. These findings reveal normal human V-SVZ development, highlighting the consequences of disease pathologies such as congenital hydrocephalus.