Open AccessA mesodermal fate map for adipose tissue
Author(s) -
Zachary L Sebo,
Elise Jeffery,
Brandon Holtrup,
Matthew S. Rodeheffer
Publication year - 2018
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.754
H-Index - 325
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.166801
Subject(s) - biology , adipocyte , adipose tissue , fate mapping , context (archaeology) , ontogeny , gastrulation , embryonic stem cell , lineage (genetic) , microbiology and biotechnology , transdifferentiation , progenitor cell , endocrinology , embryo , embryogenesis , stem cell , genetics , gene , paleontology
The embryonic origin of distinct fat depots and the role for ontogeny in specifying the functional differences among adipocyte lineages between and within depots is unclear. Using a Cre/Lox-based strategy to track the fate of major mesodermal subcompartments in mice we present evidence that fewer than 50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation and that perigonadal adipocytes arise from separate mesodermal subcompartments in males and females. Last, we show adipocyte precursors (APs) of distinct lineages within the same depot exhibit indistinguishable responses to a high fat diet, indicating ontogenetic differences between APs do not necessarily correspond to functional differences in this context. Altogether, these findings shed light on adipose tissue patterning and suggest the behavior of adipocyte lineage cells is not strictly determined by developmental history.