The hematopoietic stem cell niche: from embryo to adult | Zendy

Xin Gao | Zendy; Chunliang Xu | Zendy; Noboru Asada | Zendy; Paul S. Frenette | Zendy

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The hematopoietic stem cell niche: from embryo to adult

Author(s) -

Xin Gao,

Chunliang Xu,

Noboru Asada,

Paul S. Frenette

Publication year - 2018

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.15

H-Index - 36

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.139691

Subject(s) - biology , niche , stem cell , haematopoiesis , mesonephros , microbiology and biotechnology , bone marrow , ecological niche , embryo , hematopoietic stem cell , stem cell niche , immunology , embryonic stem cell , genetics , progenitor cell , ecology , gene , habitat

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.

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