Open AccessControl ofDrosophilatype I and type II central brain neuroblast proliferation bybantammicroRNA
Author(s) -
Ruifen Weng,
Stephen M. Cohen
Publication year - 2015
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.15
H-Index - 36
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.127209
Subject(s) - neuroblast , biology , microrna , neural stem cell , microbiology and biotechnology , progenitor cell , progenitor , stem cell , cell type , neurogenesis , neuroscience , cell , genetics , gene
Post-transcriptional regulation of stem cell self-renewal by microRNAs is emerging as an important mechanism controlling tissue homeostasis. Here, we provide evidence that bantam microRNA controls neuroblast number and proliferation in the Drosophila central brain. Bantam also supports proliferation of transit-amplifying intermediate neural progenitor cells in type II neuroblast lineages. The stem cell factors brat and prospero are identified as bantam targets acting on different aspects of these processes. Thus, bantam appears to act in multiple regulatory steps in the maintenance and proliferation of neuroblasts and their progeny to regulate growth of the central brain.