Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans | Zendy

William G. Kelly | Zendy; Andrew Fire | Zendy

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Chromatin silencing and the maintenance of a functional germline in Caenorhabditis elegans

Author(s) -

William G. Kelly,

Andrew Fire

Publication year - 1998

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.125.13.2451

Subject(s) - biology , caenorhabditis elegans , germline , gene silencing , genetics , mutant , chromatin , genetic screen , microbiology and biotechnology , gene , rna interference , transgene , rna

The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing mechanism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and mes-6. The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman, R., Nehrt, S. and Strome, S. (1998). Development 125, 2457-2467; Korf, I., Fan, F. and Strome, S. (1998). Development 125, 2469-2478). These results suggest that a genetic silencing process is essential for sustained germline function, and that this silencing is mediated, at least in part, by Polycomb Group proteins.

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