Genetics of intercellular signalling in C. elegans | Zendy

Judith Austin | Zendy; Eleanor M. Maine | Zendy; Judith Kimble | Zendy

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Genetics of intercellular signalling in C. elegans

Author(s) -

Judith Austin,

Eleanor M. Maine,

Judith Kimble

Publication year - 1989

Publication title -

development

Language(s) - English

Resource type - Journals

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.107.supplement.53

Subject(s) - biology , caenorhabditis elegans , germline , somatic cell , cell fate determination , microbiology and biotechnology , embryonic induction , gene , genetics , cell , intracellular , mitosis , cell growth , embryonic stem cell , transcription factor , mesoderm

Cell–cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans. It has been found that two genes, glp-1 and lin-12, are required for many of these decisions, glp-1 is required for induction of mitotic proliferation in the germline by the somatic distal tip cell and for induction of the anterior pharynx early in embryogenesis. lin-12 is required for the interactions between cells of equivalent developmental potential, which allow them to take on different fates. Comparison of these two genes on a molecular level indicates that they are similar in sequence and organization, suggesting that the mechanisms of these two different sets of cell–cell interactions are similar.

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