Gcn5 histone acetyltransferase is present in the mitoplasts | Zendy

Arianna Montanari | Zendy; Manuela Leo | Zendy; Veronica De Luca | Zendy; Patrizia Filetici | Zendy; Silvia Francisci | Zendy

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Gcn5 histone acetyltransferase is present in the mitoplasts

Author(s) -

Arianna Montanari,

Manuela Leo,

Veronica De Luca,

Patrizia Filetici,

Silvia Francisci

Publication year - 2019

Publication title -

biology open

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.936

H-Index - 41

ISSN - 2046-6390

DOI - 10.1242/bio.041244

Subject(s) - biology , histone acetyltransferase , acetylation , acetyltransferase , histone , lysine , mitochondrion , saccharomyces cerevisiae , epigenetics , genetics , phenotype , microbiology and biotechnology , biochemistry , gene , amino acid

In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that G CN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present in the mitoplasts, suggesting a new mitochondrial function independent from the SAGA complex and possibly a new function for this protein connecting epigenetics and metabolism.

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