Open AccessImidapril Inhibits Cerebral Aneurysm Formation in an Angiotensin-Converting Enzyme–Independent and Matrix Metalloproteinase-9–Dependent Manner
Author(s) -
Ryota Ishibashi,
Tomohiro Aoki,
Masaki Nakagawa,
Susumu Miyamoto
Publication year - 2012
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.485
H-Index - 34
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1227/neu.0b013e3182326188
Subject(s) - pathogenesis , medicine , angiotensin converting enzyme , immunostaining , ace inhibitor , matrix metalloproteinase , western blot , angiotensin ii , downregulation and upregulation , pharmacology , endocrinology , receptor , chemistry , immunohistochemistry , biochemistry , blood pressure , gene
Cerebral aneurysms (CAs) have a high prevalence in the general population and cause lethal subarachnoid hemorrhage. We recently demonstrated that chronic inflammation is an underlying pathogenesis of CA. However, we identified the negative involvement of angiotensin receptor signaling in the pathogenesis of CA.