Open AccessMelanocytic Colonization of a Meningothelial Meningioma: Histopathological and Ultrastructural Findings with Immunohistochemical and Genetic Correlation: Case Report
Author(s) -
Scott L. Nestor,
Arie Perry,
Özlem Kurtkaya,
Patrice C. Abell-Aleff,
Aldo M. Rosemblat,
Peter C. Burger,
Bernd W. Scheithauer
Publication year - 2003
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.485
H-Index - 34
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1227/01.neu.0000068990.79680.f6
Subject(s) - meningioma , medicine , pathology , craniotomy , immunohistochemistry , colonization , fluorescence in situ hybridization , biology , radiology , biochemistry , gene , microbiology and biotechnology , chromosome
OBJECTIVE AND IMPORTANCE Melanocytic colonization of nonpigmented extracranial tumors has been reported in adenocarcinomas, squamous cell carcinomas, skin appendage tumors, and dermatofibrosarcoma protuberans. To our knowledge, melanocytic colonization of a meningioma has not previously been described. CLINICAL PRESENTATION We report an unusual case of a 70-year-old African-American woman who presented with a large frontoparietal meningioma that extended through the calvarium. INTERVENTION Craniotomy with gross total resection of the tumor was performed. Histochemistry, immunocytochemistry, ultrastructural analysis, and molecular genetic study via fluorescence in situ hybridization confirmed melanocytic colonization of a meningothelial meningioma. CONCLUSION With the inclusion of meningothelial meningioma, the spectrum of tumors affected by melanocytic colonization continues to expand.