Open AccessRole of the bcl-2 Gene after Contusive Spinal Cord Injury in Mice
Author(s) -
Takahiro Seki,
Kazutoshi Hida,
Mitsuhiro Tada,
Izumi Koyanagi,
Yoshinobu Iwasaki
Publication year - 2003
Publication title -
neurosurgery/neurosurgery online
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.485
H-Index - 34
eISSN - 1081-1281
pISSN - 0148-396X
DOI - 10.1227/01.neu.0000068988.28788.2c
Subject(s) - medicine , spinal cord injury , apoptosis , lesion , spinal cord , hindlimb , oncogene , genetically modified mouse , pathology , anesthesia , transgene , gene , biology , cancer , biochemistry , psychiatry , cell cycle
Apoptosis is indicated to have an important role in the secondary injury mechanisms of acute spinal cord injury (SCI). The proto-oncogene bcl-2 has been demonstrated to prevent apoptotic cell death in a wide variety of cell types. This study examined the recovery of behavioral function and histopathological variables after controlled-impact SCI in human bcl-2 transgenic (TG) mice and control mice.