Open AccessInhibition by Local Bupivacaine-Releasing Microspheres of Acute Postoperative Pain from Hairy Skin Incision
Author(s) -
Rachit Ohri,
Jeffrey Chi Fei Wang,
Phillip D. Blaskovich,
Lan Pham,
Daniel Costa,
Gary Nichols,
William Hildebrand,
Nelson Scarborough,
Clifford Herman,
Gary R. Strichartz
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182a00851
Subject(s) - medicine , bupivacaine , anesthesia , hyperalgesia , allodynia , surgery , microsphere , nociception , chemical engineering , engineering , receptor
Acute postoperative pain causes physiological deficits and slows recovery. Reduction of such pain by local anesthetics that are delivered for several days postoperatively is a desirable clinical objective, which is approached by a new formulation and applied in animal studies reported here.