Open AccessPolyuria Related to Dexmedetomidine
Author(s) -
Alexandra Pratt,
Matthew Aboudara,
Linn Lung
Publication year - 2013
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3182917c86
Subject(s) - dexmedetomidine , medicine , polyuria , anesthesia , bradycardia , discontinuation , sedative , vasopressin , analgesic , anxiolytic , anesthetic , sedation , heart rate , endocrinology , receptor , blood pressure , diabetes mellitus
Dexmedetomidine has become a popular sedative in the intensive care unit for patients undergoing mechanical ventilation because of its highly selective α-2 agonism, which exerts a combination of anesthetic, analgesic, and anxiolytic effects. Bradycardia and hypotension have been reported as the most common side effects of its use in large studies. Dexmedetomidine has been reported to induce polyuria by suppressing vasopressin secretion and increasing permeability of the collecting ducts in a dose-dependent fashion. We report a case of dexmedetomidine-related polyuria that occurred with a high-dose continuous infusion and subsequently resolved with discontinuation of the drug. (Anesth Analg 2013;117:150-2).