The Mu Opioid Receptor Modulates Neurotransmission in the Rat Spinal Ventral Horn | Zendy

Hiroyuki Honda | Zendy; Yasuhiko Kawasaki | Zendy; Hiroshi Baba | Zendy; Tatsuro Kohno | Zendy

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The Mu Opioid Receptor Modulates Neurotransmission in the Rat Spinal Ventral Horn

Author(s) -

Hiroyuki Honda,

Yasuhiko Kawasaki,

Hiroshi Baba,

Tatsuro Kohno

Publication year - 2012

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e318259393d

Subject(s) - damgo , excitatory postsynaptic potential , inhibitory postsynaptic potential , neurotransmission , neuroscience , reversal potential , tetrodotoxin , medicine , enkephalin , biophysics , opioid , chemistry , patch clamp , receptor , biology

Opioids inhibit excitatory neurotransmission and produce antinociception through μ opioid receptors (MORs). Although MORs are expressed in the spinal ventral horn, their functions and effects are largely unknown. Therefore, we examined the neuromodulatory effects of μ opioids in spinal lamina IX neurons at the cellular level.

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