Open AccessThe Mu Opioid Receptor Modulates Neurotransmission in the Rat Spinal Ventral Horn
Author(s) -
Hiroyuki Honda,
Yuki Kawasaki,
Hiroshi Baba,
Tatsuro Kohno
Publication year - 2012
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318259393d
Subject(s) - damgo , excitatory postsynaptic potential , inhibitory postsynaptic potential , neurotransmission , neuroscience , reversal potential , tetrodotoxin , medicine , enkephalin , biophysics , opioid , chemistry , patch clamp , receptor , biology
Opioids inhibit excitatory neurotransmission and produce antinociception through μ opioid receptors (MORs). Although MORs are expressed in the spinal ventral horn, their functions and effects are largely unknown. Therefore, we examined the neuromodulatory effects of μ opioids in spinal lamina IX neurons at the cellular level.