Open AccessApparent Dexmedetomidine-Induced Polyuric Syndrome in an Achondroplastic Patient Undergoing Posterior Spinal Fusion
Author(s) -
Allison Greening,
Letha Mathews,
James Blair
Publication year - 2011
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31823299c1
Subject(s) - medicine , dexmedetomidine , anesthesia , sufentanil , polyuria , lidocaine , isoflurane , urine osmolality , vasopressin , sedation , endocrinology , diabetes mellitus
A 40-year-old achondroplastic patient underwent posterior spinal fusion under general endotracheal anesthesia. Anesthesia was maintained with isoflurane, and sufentanil, dexmedetomidine, and lidocaine infusions. Urine output increased from 150 mL/hr to 950 mL/hr the fourth hour. An increasing serum sodium, low urine-specific gravity, and increased serum osmolarity occurred simultaneously with the polyuria. Within 2 hours of discontinuing the dexmedetomidine infusion urine output greatly decreased. Within 24 hours all signs of the polyuric syndrome resolved spontaneously. Alpha(2) agonists block arginine-vasopressin release and action; however, a polyuric syndrome has not been reported in the human literature.