Open AccessInteractions of Midazolam and Propofol on α1β2γ2L and α1β2γ2S Gamma Aminobutyric Acid Type A Receptors Expressed in Human Embryonic Kidney Cells
Author(s) -
Deok Man Hong,
Chong Sung Kim,
Woosik Eom,
Kyung Ho Choi,
Yun Jung Oh,
Sung Jun Jung,
HeeSoo Kim
Publication year - 2011
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31820fcc3e
Subject(s) - gabaa receptor , midazolam , propofol , gabaa rho receptor , pharmacology , receptor , medicine , benzodiazepine , sedation
The gamma aminobutyric acid type A (GABA(A)) receptor is a prime target of many anesthetics, including midazolam and propofol. Although these anesthetics have sedative and hypnotic properties by enhancing GABA(A) receptor activity, their interactions at the GABA(A) receptors have not been explored. We investigated the interaction of midazolam and propofol with α(1)β(2)γ(2)L and α(1)β(2)γ(2)S GABA(A) receptors.