Open AccessCyclooxygenase Inhibition in Ventilator-Induced Lung Injury
Author(s) -
Takehiro Niitsu,
Shinya Tsuchida,
Vanya D. Peltekova,
Doreen Engelberts,
Ian B. Copland,
Gail Otulakowski,
Martin Post,
Brian P. Kavanagh
Publication year - 2011
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181fe4841
Subject(s) - medicine , cyclooxygenase , eicosanoid , pharmacology , tumor necrosis factor alpha , lung , eicosanoid metabolism , pulmonary edema , in vivo , edema , ibuprofen , immunology , chemistry , biology , arachidonic acid , enzyme , biochemistry , microbiology and biotechnology
We tested the hypothesis that inhibition of cyclooxygenase (COX) attenuates in vivo ventilator-induced lung injury (VILI) in a prospective, randomized laboratory investigation in a university-affiliated laboratory. Adult male rats were anesthetized and randomized with or without nonselective COX inhibition (ibuprofen) and were subjected to injurious mechanical ventilation (positive end-expiratory pressure = 0; peak inspiratory pressure = 21 mm Hg).