Cyclooxygenase Inhibition in Ventilator-Induced Lung Injury | Zendy

Takehiro Niitsu | Zendy; Shinya Tsuchida | Zendy; Vanya Peltekova | Zendy; Doreen Engelberts | Zendy; Ian B. Copland | Zendy; Gail Otulakowski | Zendy; Martin Post | Zendy; Brian P. Kavanagh | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cyclooxygenase Inhibition in Ventilator-Induced Lung Injury

Author(s) -

Takehiro Niitsu,

Shinya Tsuchida,

Vanya Peltekova,

Doreen Engelberts,

Ian B. Copland,

Gail Otulakowski,

Martin Post,

Brian P. Kavanagh

Publication year - 2010

Publication title -

anesthesia and analgesia

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e3181fe4841

Subject(s) - medicine , cyclooxygenase , eicosanoid , pharmacology , tumor necrosis factor alpha , lung , eicosanoid metabolism , pulmonary edema , in vivo , edema , ibuprofen , immunology , chemistry , biology , arachidonic acid , enzyme , biochemistry , microbiology and biotechnology

We tested the hypothesis that inhibition of cyclooxygenase (COX) attenuates in vivo ventilator-induced lung injury (VILI) in a prospective, randomized laboratory investigation in a university-affiliated laboratory. Adult male rats were anesthetized and randomized with or without nonselective COX inhibition (ibuprofen) and were subjected to injurious mechanical ventilation (positive end-expiratory pressure = 0; peak inspiratory pressure = 21 mm Hg).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research