Open AccessThe Role of Interleukin-1 in Wound Biology. Part II
Author(s) -
Yajing Hu,
DeYong Liang,
Xiangqi Li,
Hong-Hsing Liu,
Xun Zhang,
Ming Zheng,
David L. Dill,
Xiaoshuang Shi,
Yanli Qiao,
David C. Yeomans,
Brendan Carvalho,
Martin S. Angst,
James D. Clark,
Gary Peltz
Publication year - 2010
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181f691eb
Subject(s) - chemokine , wound healing , keratinocyte , macrophage inflammatory protein , in vivo , immunology , interleukin , chemotaxis , in vitro , cytokine , biology , inflammation , medicine , receptor , biochemistry , microbiology and biotechnology
In the accompanying paper, we demonstrate that genetic variation within Nalp1 could contribute to interstrain differences in wound chemokine production through altering the amount of interleukin (IL)-1 produced. We further investigate the role of IL-1 in incisional wound biology and its effect on wound chemokine production in vivo and whether this mechanism could be active in human subjects.