Open AccessInhaled Carbon Monoxide Prevents Acute Kidney Injury in Pigs After Cardiopulmonary Bypass by Inducing a Heat Shock Response
Author(s) -
Ulrich Goebel,
Matthias Siepe,
Christian I. Schwer,
David Schibilsky,
Katharina Foerster,
Jens Neumann,
Thorsten Wiech,
HansJoachim Priebe,
Christian Schlensak,
Torsten Loop
Publication year - 2010
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181e0cca4
Subject(s) - medicine , acute kidney injury , cardiopulmonary bypass , cystatin c , shock (circulatory) , creatinine , heat shock protein , renal function , pharmacology , anesthesia , biochemistry , chemistry , gene
Cardiopulmonary bypass (CPB) may be associated with acute kidney injury (AKI). Inhaled carbon monoxide (CO) is cyto- and organ-protective. We hypothesized that pretreatment with inhaled CO prevents CPB-associated AKI.