Open AccessThe Effects of the Phosphodiesterase Inhibitor Olprinone on Global Cerebral Ischemia
Author(s) -
Naoko Okayama,
Akira Matsunaga,
Yasuyuki Kakihana,
Kohsho Fujikawa,
Kazuhiko Inoue,
Tetsuya Nagayama,
Masaharu Takeyama,
Atsuro Miyata,
Yuichi Kanmura
Publication year - 2010
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181cb5cdd
Subject(s) - medicine , ischemia , anesthesia , hippocampal formation , phosphodiesterase , adenosine , saline , neuroprotection , pharmacology , cerebral blood flow , phosphodiesterase inhibitor , cyclic adenosine monophosphate , receptor , biochemistry , biology , enzyme
The phosphodiesterase III inhibitor olprinone has been confirmed to improve myocardial function and increase cerebral blood flow; therefore, if olprinone exerts direct neuroprotective effects against global cerebral ischemia to the same degree as cilostazol, olprinone could be useful for cerebral resuscitation after cardiac arrest. We examined whether olprinone directly protected neuronal cells from global cerebral ischemia both in vivo and in vitro.