Open AccessDifferences in Production of Reactive Oxygen Species and Mitochondrial Uncoupling as Events in the Preconditioning Signaling Cascade Between Desflurane and Sevoflurane
Author(s) -
Filip Sedlić,
Danijel Pravdić,
Marko Ljubković,
Jasna Marinović,
Anna Stadnicka,
Željko J. Bošnjak
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e3181a93ad9
Subject(s) - desflurane , sevoflurane , reactive oxygen species , oxidative stress , mitochondrial ros , trolox , mitochondrion , uncoupling protein , medicine , pharmacology , microbiology and biotechnology , chemistry , biochemistry , biology , adipose tissue , antioxidant capacity , brown adipose tissue
Signal transduction cascade of anesthetic-induced preconditioning has been extensively studied, yet many aspects of it remain unsolved. Here, we investigated the roles of reactive oxygen species (ROS) and mitochondrial uncoupling in cardiomyocyte preconditioning by two modern volatile anesthetics: desflurane and sevoflurane.