Open AccessAprotinin Modifies Left Ventricular Contractility and Cytokine Release After Ischemia-Reperfusion in a Dose-Dependent Manner in a Murine Model
Author(s) -
Matthew D. McEvoy,
Michel J. Sabbagh,
Anna Greta B. Taylor,
Juozas A. Zavadzkas,
Christine N. Koval,
Robert E. Stroud,
Ralph Ford,
Julie E. McLean,
Scott Reeves,
Rupak Mukherjee,
Francis G. Spinale
Publication year - 2009
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31818cdb13
Subject(s) - medicine , contractility , aprotinin , ischemia , cytokine , cardiology , pharmacology , anesthesia
Periods of ischemia-reperfusion (I/R) during cardiac surgery are associated with transient left ventricular (LV) dysfunction and an inflammatory response. In this study, we examined the potential dose-dependent effects of aprotinin (APRO) on LV contractility and cytokine release in the setting of I/R.