Aprotinin Modifies Left Ventricular Contractility and Cytokine Release After Ischemia-Reperfusion in a Dose-Dependent Manner in a Murine Model | Zendy

Matthew D. McEvoy | Zendy; Michel J. Sabbagh | Zendy; Anna Greta B. Taylor | Zendy; Juozas A. Zavadzkas | Zendy; Christine N. Koval | Zendy; Robert E. Stroud | Zendy; Rachael Ford | Zendy; Julie E. McLean | Zendy; Scott T. Reeves | Zendy; Rupak Mukherjee | Zendy; Francis G. Spinale | Zendy

Open Access

Aprotinin Modifies Left Ventricular Contractility and Cytokine Release After Ischemia-Reperfusion in a Dose-Dependent Manner in a Murine Model

Author(s) -

Matthew D. McEvoy,

Michel J. Sabbagh,

Anna Greta B. Taylor,

Juozas A. Zavadzkas,

Christine N. Koval,

Robert E. Stroud,

Rachael Ford,

Julie E. McLean,

Scott T. Reeves,

Rupak Mukherjee,

Francis G. Spinale

Publication year - 2009

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e31818cdb13

Subject(s) - medicine , contractility , aprotinin , ischemia , cytokine , cardiology , pharmacology , anesthesia

Periods of ischemia-reperfusion (I/R) during cardiac surgery are associated with transient left ventricular (LV) dysfunction and an inflammatory response. In this study, we examined the potential dose-dependent effects of aprotinin (APRO) on LV contractility and cytokine release in the setting of I/R.

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