The Effects of Volatile Aromatic Anesthetics on Voltage-Gated Na+ Channels Expressed in Xenopus Oocytes | Zendy

Takafumi Horishita | Zendy; Edmond I. Eger | Zendy; R. Adron Harris | Zendy

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The Effects of Volatile Aromatic Anesthetics on Voltage-Gated Na+ Channels Expressed in Xenopus Oocytes

Author(s) -

Takafumi Horishita,

Edmond I. Eger,

R. Adron Harris

Publication year - 2008

Publication title -

anesthesia and analgesia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.404

H-Index - 201

eISSN - 1526-7598

pISSN - 0003-2999

DOI - 10.1213/ane.0b013e318184b966

Subject(s) - hexafluorobenzene , sodium channel , xenopus , biophysics , sodium , depolarization , butyric acid , pharmacology , chemistry , stereochemistry , medicine , biochemistry , biology , benzene , organic chemistry , gene

Many inhaled anesthetics inhibit voltage-gated sodium channels at clinically relevant concentrations, and suppression of neurotransmitter release by these anesthetics results, at least partly, from decreased presynaptic sodium channel activity. Volatile aromatic anesthetics can inhibit N-methyl-D-aspartate (NMDA) receptor function and enhance gamma-amino butyric acid A receptor function, but these effects depend strongly on the chemical properties of the aromatic compounds. In the present study we tested whether diverse aromatic anesthetics consistently inhibit sodium channel function.

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