Open AccessSevoflurane and the Feto-Placental Vasculature: The Role of Nitric Oxide and Vasoactive Eicosanoids
Author(s) -
Rachel A. Farragher,
Chris Maharaj,
Brendan D. Higgins,
Sharon Crowe,
Padvaic Burke,
Christopher D Laffey,
Noel M. Flynn,
John G. Laffey
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318173465e
Subject(s) - sevoflurane , vasodilation , medicine , nitric oxide , anesthesia , pharmacology , prostacyclin , nitric oxide synthase , thromboxane a2 , endocrinology , receptor
The effects and mechanisms of action of volatile anesthetics on the feto-placental vasculature are not known. We aimed to quantify the vasoactive effects of sevoflurane and determine the role of nitric oxide (NO) and of vasoactive eicosanoids in mediating these effects in isolated human chorionic plate arterial rings.