Open AccessPropofol Sedation Is Reduced by Δ9-Tetrahydrocannabinol in Mice
Author(s) -
Philipp-Alexander Brand,
Andrea Paris,
Berthold Bein,
Patrick Meybohm,
Jens Scholz,
Henning Ohnesorge,
Peter H. Tonner
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318173287a
Subject(s) - medicine , propofol , sedation , tetrahydrocannabinol , anesthesia , pharmacology , cannabinoid , receptor
Delta9-tetrahydrocannabinol (Delta9-THC) induces analgesic effects and alterations of alertness. It has been reported that propofol increases endocannabinoid levels in the brain, but the effects of Delta9-THC on propofol sedation remain unclear. Our aim was to characterize the interaction between Delta9-THC and propofol in terms of sedation and analgesia.