Open AccessThe Effects of Intrathecal Cyclooxygenase-1, Cyclooxygenase-2, or Nonselective Inhibitors on Pain Behavior and Spinal Fos-Like Immunoreactivity
Author(s) -
Il Ok Lee,
Youngsun Seo
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318163f602
Subject(s) - ketorolac , celecoxib , medicine , cyclooxygenase , spinal cord , nociception , pharmacology , anesthesia , analgesic , receptor , enzyme , chemistry , biochemistry , psychiatry
Prostaglandins are synthesized by cyclooxygenase (COX) and are thought to play an important role in nociceptive transmission in the spinal cord. Fos expression is an indicator of spinal neuron activation. We examined the role of intrathecal selective and nonspecific COX inhibitors on spinal C-Fos expression.