Open AccessMorphine Attenuates Microvascular Hyperpermeability via a Protein Kinase A-Dependent Pathway
Author(s) -
Rudolph Puana,
Russell K. McAllister,
Felicia A. Hunter,
Julie Warden,
Ed W. Childs
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318160648b
Subject(s) - medicine , pharmacology , morphine , protein kinase a , anesthesia , kinase , microbiology and biotechnology , biology
A recently published study from our laboratory demonstrated that morphine sulfate (MS) attenuates microvascular hyperpermeability after hemorrhagic shock in rats. MS binds to the mu receptors located on the surface of endothelial cells. Activation of the endothelial cell mu receptors has been shown by several investigators to stimulate adenylate cyclase. We hypothesize that MS binding to the mu receptor on endothelial cells increases cyclic adenosine monophosphate via adenylate cyclase activation. Cyclic adenosine monophosphate inhibits the phosphoinositide/MAP kinase hyperpermeability pathway via the protein kinase A (PKA)-dependent inhibition of Raf-1.