Open AccessThe Comparative Abilities of Propofol and Sevoflurane to Modulate Inflammation and Oxidative Stress in the Kidney After Aortic Cross-Clamping
Author(s) -
Pilar Sánchez-Conde,
José M. Rodríguez-López,
Juan L. Nicolás,
Francisco Lozano,
Francisco Javier GarcíaCriado,
Carlos Cascajo,
Rogelio González-Sarmiento,
Carlos Muñiz Muriel
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e318160580b
Subject(s) - medicine , sevoflurane , propofol , nitric oxide synthase , oxidative stress , anesthesia , kidney , myeloperoxidase , creatinine , nitric oxide , endocrinology , inflammation
Propofol has been reported to provide protection against ischemia-reperfusion injury. Nuclear transcription factor kappa B (NFkappaB) plays a key role in oxidative stress and the inflammatory response during ischemia-reperfusion. We compared the effect of propofol with sevoflurane on kidney NFkappaB expression and systemic inflammatory responses induced by aortic clamping.