Open AccessThe Limited Efficacy of Tramadol in Postoperative Patients: A Study of ED80 Using the Continual Reassessment Method
Author(s) -
Aude Thévenin,
Hélène Beloeil,
Antonia Blanié,
Dan Benhamou,
JeanXavier Mazoit
Publication year - 2008
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0b013e31816053aa
Subject(s) - tramadol , medicine , anesthesia , confidence interval , clinical trial , cohort , prospective cohort study , surgery , analgesic
The aim of this study was to reevaluate the efficacy of tramadol for postoperative analgesia and to determine its ED80 (the clinical dose for which 80% of the patients had their pain adequately relieved) using the Continual Reassessment Method. Because the preliminary results of the first 24 patients were contradictory to the literature, we performed a second trial to verify and validate our data.