Open AccessSpinal Neuronal GRK2 Contributes to Preventive Effect by Electroacupuncture on Cisplatin-Induced Peripheral Neuropathy in Mice
Author(s) -
Xue Ma,
Yu Chen,
Xiaochen Li,
Wen-Li Mi,
YuXia Chu,
Yanqing Wang,
Qi-Liang Mao-Ying
Publication year - 2021
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005768
Subject(s) - medicine , spinal cord , microglia , proinflammatory cytokine , pharmacology , neuropathic pain , electroacupuncture , peripheral neuropathy , endocrinology , pathology , inflammation , acupuncture , psychiatry , diabetes mellitus , alternative medicine
The main symptoms of chemotherapy-induced peripheral neuropathy (CIPN) include pain and numbness. Neuronal G protein-coupled receptor kinase 2 (GRK2) plays an important role in various pain models. Cisplatin treatment can induce the activation of proinflammatory microglia in spinal cord. The purpose of this study was to investigate the role of spinal neuronal GRK2 in cisplatin-induced CIPN and in the prevention of CIPN by electroacupuncture (EA).