Open AccessThe Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines
Author(s) -
Huiling Tan,
ZhenDong Ding,
ChengLiang Zhang,
Jianqin Yan,
Yong Yang,
Ping Li
Publication year - 2021
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005737
Subject(s) - medicine , pregnancy , tumor necrosis factor alpha , western blot , programmed cell death , spinal cord , inflammation , interleukin , gestation , andrology , endocrinology , immunology , apoptosis , cytokine , biology , biochemistry , genetics , psychiatry , gene
The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. We examined the relationship between the antinociceptive effect and the expression level of programmed cell death ligand-1 (PD-L1) during pregnancy and further observed the changes in pain thresholds and expression levels of cytokines in late-pregnant mice before and after blockade of PD-L1 or programmed cell death-1 (PD-1).