Open AccessThe Effects of Intraoperative Caffeine on Postoperative Opioid Consumption and Related Outcomes After Laparoscopic Surgery: A Randomized Controlled Trial
Author(s) -
Phillip E. Vlisides,
Duan Li,
Amy S McKinney,
Joseph Brooks,
Aleda Leis,
Graciela Mentz,
Alexander Tsodikov,
Mackenzie Zierau,
Jacqueline Ragheb,
Daniel J. Clauw,
Michael S. Avidan,
Giancarlo Vanini,
George A. Mashour
Publication year - 2021
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005532
Subject(s) - medicine , anesthesia , interquartile range , randomized controlled trial , opioid , placebo , adverse effect , emergence delirium , surgery , sevoflurane , alternative medicine , receptor , pathology
Surgical patients are vulnerable to opioid dependency and related risks. Clinical-translational data suggest that caffeine may enhance postoperative analgesia. This trial tested the hypothesis that intraoperative caffeine would reduce postoperative opioid consumption. The secondary objective was to assess whether caffeine improves neuropsychological recovery postoperatively.