Open AccessPrevention of Cardiac Surgery–Associated Acute Kidney Injury by Implementing the KDIGO Guidelines in High-Risk Patients Identified by Biomarkers: The PrevAKI-Multicenter Randomized Controlled Trial
Author(s) -
Alexander Zarbock,
Mira Küllmar,
Marlies Ostermann,
Gianluca Lucchese,
Kamran Baig,
Armando Cennamo,
Ronak Rajani,
Stuart McCorkell,
Christian Arndt,
Hinnerk Wulf,
Marc Irqsusi,
Fabrizio Monaco,
Ambra Licia Di Prima,
Mercedes García Álvarez,
Stefano Italiano,
Jordi Miralles Bagán,
Gudrun Kunst,
Shrijit Nair,
Camilla L’Acqua,
Eric A. J. Hoste,
Wim Vandenberghe,
Patrick M. Honoré,
John A. Kellum,
Lui G. Forni,
Philippe Grieshaber,
Christina Massoth,
Raphael Weiß,
Joachim Gerß,
Carola Wempe,
Melanie Meersch
Publication year - 2021
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000005458
Subject(s) - medicine , acute kidney injury , kidney disease , randomized controlled trial , clinical endpoint , multicenter trial , confidence interval , relative risk , surgery , intensive care medicine , multicenter study
Prospective, single-center trials have shown that the implementation of the Kidney Disease: Improving Global Outcomes (KDIGO) recommendations in high-risk patients significantly reduced the development of acute kidney injury (AKI) after surgery. We sought to evaluate the feasibility of implementing a bundle of supportive measures based on the KDIGO guideline in high-risk patients undergoing cardiac surgery in a multicenter setting in preparation for a large definitive trial.